Does vancomycin follow linear kinetics?
Does vancomycin follow linear kinetics?
Remember vancomycin has LINEAR kinetics! Changes in dose should produce proportional changes in serum level, as long as the dosing interval remains constant. So a simple proportion is often all that is required to find your new regimen.
What is Vanco dosing?
Typically 15 to 20 mg/kg every 8 to 12 hours for most patients (based on actual body weight, rounded to the nearest 250 mg increment). In general, the approach to establishing the vancomycin dose/interval is guided by a nomogram. Δ
How is Cl Vanco calculated?
Clearance
- CLvanco (mL/min/kg) = ([CrCl × 0.0075] + 0.04)
- Vd = 0.47 L/kg. Vd was estimated using an adjusted body weight (ABW).
How do you calculate vancomycin peak?
Using the first-order elimination equation (Cp=Cp0∗e−kt), a true peak (Cmax) can be calculated using the time elapsed between the end of the vancomycin infusion and the first drug concentration (Cp0).
What is vancomycin AUC dosing?
AUC vancomycin dosing represents the total vancomycin concentration in the blood over a period of time, usually over 24 hours. In order to calculate this manually: Two vancomycin levels need to be drawn when the patient’s vancomycin is at a stable concentration, usually referred to as steady-state.
When do you draw a Vanco trough?
Trough: just before 4th dose of a new regimen (prior to 3rd dose for dosing intervals ≥ 24 hours or changing renal function) – Trough levels should be obtained within 30 minutes before the next scheduled dose. – Weekly vancomycin levels should be obtained for long-term vancomycin use with stable renal function. i.
How much is vancomycin IV?
The cost for vancomycin intravenous powder for injection 1 g is around $45 for a supply of 10 powder for injection, depending on the pharmacy you visit….Intravenous Powder For Injection.
| Quantity | Per unit | Price |
|---|---|---|
| 1 | $26.26 – $30.23 | $26.26 – $30.23 |
How do you calculate AUC over MIC?
First, divide the total daily dose of vancomycin by the estimated clearance of vancomycin. Then divide this number by the MIC. The formula can be expressed as this: ((daily vancomycin dose)/(ClCr*0.75*0.06))/(MIC).
