Why can t you have oxygen after bleomycin?
Why can t you have oxygen after bleomycin?
Exposure to bleomycin appears to sensitise the lungs and potentially fatal acute lung damage can occur at an inspired oxygen concentration which is otherwise considered normal for a healthy individual.
How does chemo affect anesthesia?
The myocardial depressant effect of the commonly used anaesthetic agents may be compounded by the previous exposure to chemotherapy agents, even in patients with apparently normal cardiac function. As a consequence, all these patients should be treated as high risk for potential cardiac events during anaesthesia.
What is bleomycin toxicity?
Bleomycin is an antineoplastic agent with potential for producing pulmonary toxicity, attributed in part to its free radical-promoting ability. Clinical and research experiences have suggested that the risk of bleomycin-induced pulmonary injury is increased with the administration of oxygen.
Is anesthesia given during chemotherapy?
A growing number of patients undergo surgical procedures with general anaesthesia soon after receiving chemotherapy; occasionally such treatment can be given during surgery.
What does bleomycin do to your lungs?
The major limitation of bleomycin therapy is the potential for life-threatening interstitial pulmonary fibrosis (also called fibrosing alveolitis) in up to 10 percent of patients receiving the drug [2-5]. Other, less common forms of lung injury include organizing pneumonia and hypersensitivity pneumonitis [3].
What do you feel in general anesthesia?
Although every person has a different experience, you may feel groggy, confused, chilly, nauseated, scared, alarmed, or even sad as you wake up. Depending on the procedure or surgery, you may also have some pain and discomfort afterward, which the anesthesiologist can relieve with medications.
Why does bleomycin accumulate in the lungs?
The mechanism of bleomycin-induced pneumonitis (BIP) involves oxidative damage, relative deficiency of the deactivating enzyme bleomycin hydrolase, genetic susceptibility, and the elaboration of inflammatory cytokines. Ultimately, BIP can progress to lung fibrosis.
