Can I take HRT if I have endometrial hyperplasia?

Can I take HRT if I have endometrial hyperplasia?

The use of continuous combined hormone replacement therapy, consisting of an oestrogen and a progestogen taken daily by postmenopausal women, is increasing. Its possible benefits are the prevention of endometrial hyperplasia and reduction in the occurrence of endometrial bleeding with time.

Does HRT increase endometrial thickness?

Conclusions: Postmenopausal women treated with HRT have a larger uterus and thicker endometrium than those of non-treated matched controls. There is a negative correlation between menopausal age and uterine and ovarian size.

How do you get rid of endometrial hyperplasia?

In many cases, endometrial hyperplasia can be treated with progestin. Progestin is given orally, in a shot, in an intrauterine device (IUD), or as a vaginal cream. How much and how long you take it depends on your age and the type of hyperplasia. Treatment with progestin may cause vaginal bleeding like a period.

How long do you take progesterone for endometrial hyperplasia?

Studies have shown regression of hyperplasia without atypia to normal endometrium in 80 to 90% of patients when treated with either medroxyprogesterone acetate (MPA), 10 mg daily for 12 to 14 days each month, or micronized progesterone in vaginal cream, when treated for 3 to 6 months.

Can I have HRT after ablation?

Women who have had an endometrial ablation (an operation to remove the lining of the womb which is often performed for very heavy periods) should also receive progestogen in case any part of the endometrium is left. Combined HRT is available in the form of either a tablet or a patch.

How do you fix thick endometrium?

The most common treatment is progestin. This can be taken in several forms, including pill, shot, vaginal cream, or intrauterine device. Atypical types of endometrial hyperplasia, especially complex, increase your risk of getting cancer. If you have these types, you might consider a hysterectomy.

What is the most common age to get endometrial hyperplasia?

Women who are perimenopausal or menopausal are more likely to have endometrial hyperplasia. It rarely occurs in women younger than 35. Other risk factors include: Certain breast cancer treatments (tamoxifen).

What is the most common cause of endometrial thickening?

The most common cause of endometrial hyperplasia is having too much estrogen and not enough progesterone. That leads to cell overgrowth. There are several reasons you might have a hormonal imbalance: You’ve reached menopause.

Can endometrial hyperplasia go away on its own?

Endometrial hyperplasia is an increased growth of the endometrium. Unlike a cancer, mild or simple hyperplasia can go away on its own or with hormonal treatment. The most common type of hyperplasia, simple hyperplasia, has a very small risk of becoming cancerous.

What hormone promotes and maintains endometrial lining?

The female hormones—estrogen and progesterone—control the changes in the uterine lining. Estrogen builds up the uterine lining. Progesterone maintains and controls this growth. At the middle of the cycle (about day 14), ovulation occurs (an egg is released from the ovary).

Which HRT after endometrial ablation?

For women who are known to have endometriosis a continuous combined HRT is recommended (see below). Women who have had an endometrial ablation (an operation to remove the lining of the womb which is often performed for very heavy periods) should also receive progestogen in case any part of the endometrium is left.

What is hormone replacement therapy (HRT) for endometriosis?

Modern hormone replacement therapy (HRT) regimens contain oestrogen and progestogen, given either in a cyclical or continuous combined manner. Most endometrial biopsies from women on sequential HRT show weak secretory features.

What are the treatment options for endometrial hyperplasia?

Treatment options for endometrial hyperplasia depend on what type you have. The most common treatment is progestin. This can be taken in several forms, including pill, shot, vaginal cream, or intrauterine device. Atypical types, especially complex, increase your risk of getting cancer.

What is the prognosis of endometrial hyperplasia in HRT?

Sequential HRT is associated with a low risk of endometrial hyperplasia and atypical hyperplasia (approximately 1% for atypical hyperplasia). Regimens containing less than 10 days progestogen or lower doses of progestogen may confer a higher risk of hyperplasia, atypical hyperplasia, and adenocarcinoma.

Can continuous combined HRT transform a hyperplastic endometrium into a state of atrophy?

Early data on continuous combined HRT also suggested that it may be capable of transforming a hyperplastic endometrium into a state of atrophy. Staland reported on 22 women with endometrial hyperplasia who, after six months treatment with continuous combined HRT, were all found to have an atrophic endometrium. 35