Can spironolactone affect depression?

Can spironolactone affect depression?

Of the individual symptoms, spironolactone significantly improved irritability, depression, feeling of swelling, breast tenderness and food craving in comparison to placebo. A lasting effect of spironolactone was observed in women started with spironolactone after cross over to placebo.

Does spironolactone mess with your hormones?

What is it? Spironolactone is an anti-male hormone (anti-androgen) medication. It blocks the male hormone receptor and reduces the level of the male hormones, testosterone and DHEAS.

When do spironolactone side effects go away?

Some side effects of spironolactone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Does spironolactone help PMDD?

Bright light treatment significantly reduced depression ratings in women with premenstrual dysphoric disorder (PMDD). Compared with placebo, the aldosterone antagonist spironolactone improved irritability, depression, feelings of swelling, breast tenderness, and food craving in women with premenstrual syndrome (PMS).

Does spironolactone affect PMS?

Spironolactone (Aldactone) is a diuretic that can help ease some of the symptoms of PMS . Hormonal contraceptives. These prescription medications stop ovulation, which may bring relief from PMS symptoms.

Does spironolactone cause feminization?

Because of its antiandrogenic activity, spironolactone can, in men, cause breast tenderness, gynecomastia (breast development), feminization in general, and demasculinization, as well as sexual dysfunction including loss of libido and erectile dysfunction, although these side effects are usually confined to high doses …

Can spironolactone cause PMS symptoms?

The evidence from these studies suggests that diuretics, especially spironolactone, have a particular role in the management of the PMS symptoms of bloatedness and abdominal distension despite the fact that the underlying water retention theory remains in doubt.

What helps with PMS irritability?

Selective serotonin reuptake inhibitors (SSRIs) — which include fluoxetine (Prozac, Sarafem), paroxetine (Paxil, Pexeva), sertraline (Zoloft) and others — have been successful in reducing mood symptoms. SSRIs are the first line treatment for severe PMS or PMDD . These medications are generally taken daily.

What are the Common side effects of spironolactone?

Spironolactone causes side effects that can range from minor ones like headaches to serious complications like stomach bleeding. Stomach bleeding with signs like bloody or tar black-colored stools, coughing up blood or vomit resembling ground-coffee High potassium levels.

How to stop taking spironolactone?

Treatment options for spironolactone withdrawal involve lowering the risk of experiencing sudden water retention or increases in blood pressure levels. Research shows that gradual tapering instead of abruptly stopping the use of this medication might help reduce the risk of having withdrawal symptoms.

Can spironolactone cause or worsen depression?

By interfering with your hypothalamic-pituitary-adrenal (HPA) axis, spironolactone causes low blood pressure, headaches, fatigue, and depression. It increases the risk of blood clots.

Does spironolactone affect hormones?

Although studies do not support an association with breast cancer, as it affects sex hormones, like the birth control pill, we stay mindful of the family history. Spironolactone was originally used as a blood pressure medication and one of the reported side effects is retention of potassium in the body.