Do mice produce IL-8?
Do mice produce IL-8?
IL-8 has been proposed to contribute to chronic inflammation and cancer. However, mice do not have the IL-8 gene, so human cancer cell lines and xenograft studies have been used to study the role of IL-8 in colon and gastric carcinogenesis.
Is IL-8 a chemokine?
CXCL8 (interleukin-8) is a member of the chemokine family that acts on CXCR1 and CXCR2 receptors.
Is interleukin 8 a protein?
In humans, the interleukin-8 protein is encoded by the CXCL8 gene. IL-8 is initially produced as a precursor peptide of 99 amino acids which then undergoes cleavage to create several active IL-8 isoforms. In culture, a 72 amino acid peptide is the major form secreted by macrophages.
What does the word chemokine mean?
Definition of chemokine : any of a group of cytokines produced by various cells (as at sites of inflammation) that stimulate chemotaxis in white blood cells (such as neutrophils and T cells)
What is the NP number for interleukin 8 in macrophages?
NP_000575. NP_001341769. Interleukin 8 (IL8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. Endothelial cells store IL-8 in their storage vesicles, the Weibel-Palade bodies.
What is the function of IL 8 in neutrophils?
Function IL-8, also known as neutrophil chemotactic factor, has two primary functions. It induces chemotaxis in target cells, primarily neutrophils but also other granulocytes, causing them to migrate toward the site of infection. IL-8 also stimulates phagocytosis once they have arrived.
Where is Interleukin 8 (IL-8) stored in endothelial cells?
Endothelial cells store IL-8 in their storage vesicles, the Weibel-Palade bodies. In humans, the interleukin-8 protein is encoded by the CXCL8 gene. IL-8 is initially produced as a precursor peptide of 99 amino acids which then undergoes cleavage to create several active IL-8 isoforms.
What is the role of interleukin-8 (IL-8) in inflammation?
Interleukin-8 secretion is increased by oxidant stress, which thereby cause the recruitment of inflammatory cells and induces a further increase in oxidant stress mediators, making it a key parameter in localized inflammation. IL-8 was shown to be associated with obesity.
