How is trastuzumab administered?
How is trastuzumab administered?
by infusion, where the medicine slowly enters your blood through a drip. The first treatment usually takes about 90 minutes and further treatments take about 30 minutes. by subcutaneous injection, which is an injection into your thigh that takes a few minutes (this can only be used for breast cancer)
Which dosing is used for calculating trastuzumab?
Adjuvant Breast Cancer Dosing Schedule
| Loading dose | Subsequent doses during weekly administration |
|---|---|
| 4 mg/kg (week 1) | 2 mg/kg (weeks 2-18) |
| AC TH | |
| 4 mg/kg (week 1 of Herceptin-containing regimen) | 2 mg/kg (weeks 2-12 of Herceptin-containing regimen) |
| Monotherapy* |
How long do you take trastuzumab?
If you’re having trastuzumab to treat primary breast cancer after surgery it’s usually given for one year (around 18 cycles). If you are having trastuzumab before surgery you will usually have four to six cycles.
What chemo is given with Herceptin?
Herceptin is approved, in combination with chemotherapy (cisplatin and either capecitabine or 5-fluorouracil), for the treatment of HER2-positive metastatic cancer of the stomach or gastroesophageal junction (where the esophagus meets the stomach) in patients who have not received prior treatment for their metastatic …
How do you give IV trastuzumab?
Administer Herceptin at an initial dose of 8 mg/kg as a 90-minute intravenous infusion followed by subsequent doses of 6 mg/kg as an intravenous infusion over 30–90 minutes every three weeks until disease progression [see Important Dosing Considerations].
How do you give a trastuzumab injection?
Trastuzumab injection products come as a liquid or as a powder to be mixed with a liquid to be injected into a vein by a doctor or nurse in a hospital or medical facility. When a trastuzumab injection product is used to treat breast cancer that has spread, it is usually given once a week.
Do you dilute trastuzumab?
Using a sterile syringe, slowly inject the 20 mL of diluent into the vial containing the lyophilized cake of Herceptin. The stream of diluent should be directed into the lyophilized cake. Swirl the vial gently to aid reconstitution. DO NOT SHAKE.
How much does trastuzumab cost?
Results. Trastuzumab costs $49,915 and $28,350 per patient treated in the adjuvant and metastatic breast cancer settings, respectively; bevacizumab costs $48,490 and $39,614 per patient treated in the metastatic lung and colorectal cancer settings, respectively.
Does trastuzumab cause hair loss?
Answer: No, hair loss is not a common side effect of trastuzumab. If you are receiving trastuzumab in combination with chemotherapy, you may experience hair loss due to the chemotherapy.
What year was Herceptin approved?
Herceptin was first FDA approved in 1998 to treat HER2+ metastatic breast cancer. In 2006, the FDA approved Herceptin to treat HER2+ early breast cancer. In 2010, the FDA approved Herceptin to treat HER2+ metastatic stomach cancer.
What treatment regimen for trastuzumab should be followed?
Administer Herceptin, alone or in combination with paclitaxel, at an initial dose of 4 mg/kg as a 90-minute intravenous infusion followed by subsequent once weekly doses of 2 mg/kg as 30-minute intravenous infusions until disease progression.
What does trastuzumab bind to?
Trastuzumab binds to the extracellular domain of HER2/erbB2 (human epidermal growth factor receptor 2), which is overexpressed in certain malignancies. Trastuzumab helps to mediate antibody-dependent cellular cytotoxicity ( ADCC ) preferentially against cells that overexpress HER2.
What is the abbreviation for trastuzumab emtansine?
Trastuzumab emtansine (also known as T-DM1) is a novel antibody-drug conjugate (ADC) that contains the humanized anti-HER2 IgG1 antibody trastuzumab and DM1, a microtubule-inhibitory maytansinoid, linked through a thioether bond. Trastuzumab emtansine retains the mechanisms of action of both trastuzumab and DM1.
Is trastuzumab chemotherapy?
Trastuzumab is a type of targeted therapy drug called a monoclonal antibody. It is often given in combination with other cancer drugs such as chemotherapy. Your doctor will talk to you about this treatment and its possible side effects before you agree ( consent) to have treatment. Trastuzumab is not the same as trastuzumab emtansine (Kadcyla ® ).
