Is sildenafil citrate water soluble?
Is sildenafil citrate water soluble?
Sildenafil is marketed as the citrate salt and is 40% orally bioavailable and it is due to its low aqueous solubility (4.1 mg/mL in water) [2], [3].
Can you dissolve sildenafil?
Sildenafil rapid-dissolve lozenges have gained much attention as an effective treatment for erectile dysfunction. These lozenges disintegrate and dissolve in the mouth or beneath the tongue within 15-20 minutes.
Does sildenafil degrade over time?
Here’s the short answer: Viagra expires. As with all medications, the ingredients in Viagra break down over time. This means that the drug’s effects will become much less potent every day after it expires.
Is sildenafil hydrophobic?
Sildenafil, although a very hydrophobic drug shows a great variety of functional groups with the ability to form hydrogen bonds, as the theoretical molecular electrostatic potential surface shows (Fig. 5).
Does Viagra work if dissolved in water?
The active ingredient in the Viagra tablet is poorly soluble in water and becomes even less soluble when it reaches the small intestine where it is absorbed by the blood, Dittert said.
How do you dissolve sildenafil citrate?
A stock solution may be made by dissolving the sildenafil citrate in the solvent of choice. Sildenafil citrate is soluble in organic solvents such as DMSO and dimethyl formamide, which should be purged with an inert gas.
Can you dissolve Viagra in water?
Hot water can potentially dissolve the coating of a medication. Take Viagra with at least half to a full glass of water to help it do its job.
Can you crush Viagra and put it under your tongue?
Viagra tablets and generic sildenafil are meant to be swallowed. These tablets aren’t designed to work under the tongue.
How long is sildenafil shelf life?
All medications have an expiration date; Viagra is no different. Viagra goes bad, loses its efficacy, and renders itself ineffective if not stored properly. Viagra has a shelf life of two years (24 months). After 24 months, the drug loses its efficacy.
Does Viagra stop working after a while?
The anti-impotence drug sildenafil (Viagra) may stop working for many patients after two years, the results of a study from the United States have suggested.
Is viagra legal in Pakistan?
Viagra, a medicine for erectile dysfunction and pulmonary arterial hypertension, is unlicensed in Pakistan. Any distribution of it is illegal.
What is sildenafil citrate made out of?
In addition to the active ingredient, sildenafil citrate, each tablet contains the following inactive ingredients: microcrystalline cellulose, anhydrous dibasic calcium phosphate, croscarmellose sodium, magnesium stearate, hypromellose, titanium dioxide, lactose, triacetin, and FD & C Blue #2 aluminum lake.
What is the solubility of sildenafil citrate?
Sildenafil citrate is a white to off-white crystalline powder soluble in DMF, acetic acid and slightly soluble in methanol. Solubility of sildenafil citrate is pH dependent and it decreases with increase of pH. pH ranges between 3.7 and 3.8 and the pKa from 8.2 to 9.6.
What is the mechanism of action of sildenafil?
Upon oral administration, sildenafil selectively targets and inhibits cyclic guanosine monophosphate ( cGMP )-specific phosphodiesterase type 5 (PDE5), thereby inhibiting the PDE5-mediated degradation of cGMP found in smooth muscle and increasing cGMP availability.
What is the expiration date on sildenafil citrate tablets?
Commercially available sildenafil citrate tablets has an expiration date of 24 months after the date of manufacture when stored as directed. American Society of Health-System Pharmacists 2014; Drug Information 2014. Bethesda, MD. 2014, p. 1877
What is the volume of distribution of sildenafil?
Volume of Distribution. Although single-dose studies indicate that more than 90% of an oral sildenafil dose is absorbed from the GI tract, the drug undergoes extensive metabolism in the GI mucosa during absorption and on first pass through the liver, with only about 40% of a dose reaching systemic circulation unchanged.
