Is there a link between MTHFR and autism?
Is there a link between MTHFR and autism?
Recently, a link has been discovered between MTHFR gene mutations and autism. 98% of children affected by autism have a mutation of the MTHFR gene, which hinders the body’s ability to transform folate into methylfolate.
What does A1298C mutation mean?
The A1298C mutation, like the C677T mutation, results in a decrease in MTHFR activity that is more pronounced in the homozygous (CC) than in the heterozygous (AC) or normal (AA) states, and does not result in a thermolabile protein.
What does it mean to be positive for two copies of the C677T mutation?
If a person has two copies (homozygous) of MTHFR C677T, or has one copy of C677T and one of A1298C, then it is likely that elevated homocysteine levels are due to these inherited mutations, or that the mutations are contributing to them.
What to eat with a MTHFR mutation?
It’s not as easily used by people with an MTHFR mutation and may interfere with the absorption of l-methylfolate. Strive to eat a diet that is healthy in general and includes folate-rich foods. Leafy greens, broccoli, lentils, and many beans are great sources of folate, fiber, and other nutrients.
How common is MTHFR mutation?
There are two common types, or variants, of MTHFR mutation: C677T and A1298C. Mutations in MTHFR genes occur in approximately 25% of people of Hispanic descent and 10–15% of North American Caucasians. These mutations in rare occasions lead to high levels of homocysteine in the blood, which may contribute to numerous health conditions, such as:
How to test for MTHFR gene mutation?
You can check your MTHFR status through genetic testing. It’s an accurate way to determine any mutation in your genes, including your predisposition to certain diseases. Genetic testing requires a blood sample or a small amount of saliva. Health facilities can collect these samples.
What does the MTHFR gene mutation cause?
As mentioned previously, a defect in the MTHFR gene can cause an abnormally high level of homocysteine in your tissues. High levels of homocysteine are associated with cardiovascular disease, high blood pressure, glaucoma, ischemic stroke, and atherosclerosis.
