What disease does Porphyromonas gingivalis cause?

What disease does Porphyromonas gingivalis cause?

Porphyromonas gingivalis is a Gram-negative oral anaerobe that is involved in the pathogenesis of periodontitis, an inflammatory disease that destroys the tissues supporting the tooth, eventually leading to tooth loss.

What are the routes of canal infections?

In fact, there are many potential pathways that may allow bacteria to invade the root canal system, the most common of which is dental caries. Other common routes of infection include cracks, trauma, exposed dentinal tubules, and iatrogenic causes [21].

How does Porphyromonas gingivalis cause periodontitis?

P . gingivalis is a gram-negative oral anaerobe and considered as a main etiological factor in periodontal diseases by producing a number of virulence factors and extracellular proteases such as lipopolysaccharide, fimbria, gingipain etc., resulting in destruction of periodontal tissues (7–11).

Which microorganisms are most frequently found in infected root canals?

The results of the present study indicate that root canal infection occurs as a result of multiple microorganism activity, dominated by Gram positive bacteria. Polymicrobial anaerobic infections were also found in the root canal. Regarding the secondary infection, E. faecalis was found to be the most prevalent species.

How do you get rid of Pingivalis?

Treatment procedures of P. gingivalis–mediated diseases such as periodontitis and peri-implantitis focus on the eradication of oral pathogens at the site of infection, usually by surface debridement procedures followed by adjunctive therapies, including the use of antiseptics or/and antibiotics [61–66].

How does a root canal get infected?

The infection at the centre of a tooth (the root canal) is caused by bacteria that live in the mouth and invade the tooth. This can happen after: tooth decay. leaky fillings.

How is Porphyromonas gingivalis treated?

What does Porphyromonas gingivalis look like?

Porphyromonas gingivalis belongs to the phylum Bacteroidetes and is a nonmotile, Gram-negative, rod-shaped, anaerobic, pathogenic bacterium. It forms black colonies on blood agar.

Where are the microorganisms in root canal infections derived?

Many microorganisms found in endodontic infections are commensals in the oral cavity, which have gained entry into the pulp tissue of the root canal typically via the caries process.

What is the pathophysiology of odontogenic infections of the mouth?

Odontogenic infections are generally polymicrobial and from endogenous oral flora. They are mixed aerobic/anaerobic with 60% caused by anaerobic and aerobic bacteria, 35% by aerobic bacteria, and 5% by anaerobic bacteria only. Of the aerobic group, Streptococci comprise about 90% and Staphylococci about 5%.

What is the treatment of choice for an odontogenic abscess?

The treatment of choice for an odontogenic abscess is incision and drainage, which may be accomplished in one of three ways: (1) exposure of the pulp chamber, with extirpation of the pulp; (2) extraction of the tooth; or (3) incision into the soft tissue surface of the abscess.

Is Mpro a cysteine protease?

The Mpro enzyme resembles the structure of cysteine proteases, although in the active site the third catalytic residue is missing; thus, the active site is formed by the catalytic dyad His41-Cys145, which forms the “oxyanion hole” together with the main-chain amides of Gly143 and Ser144 (see Fig. 6 B).

What are the signs and symptoms of dental infection?

In a review of adults with prolonged fever related to dental infection, only 19% had dental symptoms. 41 Repeated examination, direct questioning about subtle dental symptoms (painful or loose teeth, discomfort with chewing or yawning, fever after eating), and performance of dental radiography lead to the diagnosis.