What does log p tell you about a drug?

What does log p tell you about a drug?

Lipophilicity is a valuable parameter of the drug which affects its activity in the human body. The Log P value of the compound indicates the permeability of the drugs to reach the target tissue in the body.

What is KPC equilibrium?

This dynamic state of equilibrium is described by the partition law or Nernst’s distribution law. This law states that the partition coefficient, or Kpc, is equal to the concentration of solute in one solvent divided by the concentration of solute in the other solvent.

What is partition coefficient in pharmacy?

The partition coefficient is the measure of the lipophilicity of a drug and an indication of its ability to cross the cell membrane. It is defined as the ratio between un-ionized drug distributed between the organic and aqueous layers at equilibrium.

Is a high partition coefficient better?

permeability of cell membranes The greater the solubility of a substance, the higher its partition coefficient, and the higher the partition coefficient, the higher the permeability of the membrane to that particular substance.

How does log p affect absorption?

High lipophilicity (logP>5) often contributes to high metabolic turnover, low solubility, and poor oral absorption. In addition, highly lipophilic compounds tend to bind to hydrophobic targets other than the desired target, and, therefore, there is an increased risk of promiscuity and toxicity.

What is partition coefficient Slideshare?

In the physical sciences, a partition-coefficient (log P) or distribution-coefficient (log D) is the ratio of concentrations of a compound in a mixture of two immiscible phases at equilibrium. These coefficients are a measure of the difference in solubility of the compound in these two phases.

What does high partition coefficient mean?

unit of measure called the partition coefficient. The greater the solubility of a substance, the higher its partition coefficient, and the higher the partition coefficient, the higher the permeability of the membrane to that particular substance.

What is the importance of partition coefficient to the pharmacist?

Partition coefficients are useful in estimating the distribution of drugs within the body. Hydrophobic drugs with high octanol-water partition coefficients are mainly distributed to hydrophobic areas such as lipid bilayers of cells.

How is partition coefficient measured?

Partition coefficient is measured as the logarithmic ratio of the concentration of the compound in the two phases. The value is a measure of hydrophobicity and hydrophilicity of the solute.

What is a high partition coefficient?

The partition-coefficient can be defined as the partition of a neutral noncharged species in to oil or water phase. Drugs with high partition-coefficient value can easily permeate through biological membrane.

What does partition coefficient mean?

partition coefficient. noun. : the ratio of the amounts of a substance distributed between two immiscible phases (as two liquids or a stationary and a mobile phase in chromatography ) at equilibrium.

What is the water partition coefficient?

n-Octanol/water partition coefficient (Kow) is defined as the ratio of the molar concentrations of a chemical in n-octanol and water, in dilute solution. The coefficient Kow is a constant for a given chemical at a given temperature.