What does protein kinase D do?
What does protein kinase D do?
Protein kinase-D (PKD) is increasingly recognized as a key regulatory signaling hub in cardiac glucose uptake and also a major player in the development of hypertrophy. Glucose is one of the predominant energy substrates for the heart to support contraction.
What happens when protein kinase is activated?
Protein kinase A (PKA) is activated by the binding of cyclic AMP (cAMP), which causes it to undergo a conformational change. As previously mentioned, PKA then goes on to phosphoylate other proteins in a phosphorylation cascade (which required ATP hydrolysis).
What happens if protein kinase is mutated?
Mutations are mostly, but not exclusively, in the kinase domain and lead to loss of catalytic activity because the mutated protein is absent, presumably as a result of destabilization and subsequent degradation.
Where is protein kinase C found?
PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+). Hence PKC enzymes play important roles in several signal transduction cascades….
| Protein kinase C | |
|---|---|
| Identifiers | |
| CAS no. | 141436-78-4 |
| Databases | |
| IntEnz | IntEnz view |
What is human Kinome?
The Human Kinome is an artistic representation of the human kinome phylogenetic tree based on extensive published research and recently annotated to include lipid, atypical and clinically-relevant mutant kinases. For lipid kinases, the kinase catalytic domains were derived from the GenPept annotation (NCBI).
What does PRKD2 stand for?
PRKD2 protein kinase D2 [ (human)] Summary. The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells.
Can PKD2 and Aurora A kinase coexist in cancer cells?
Study identified, for the first time, a functional crosstalk between protein kinase D2 (PKD2) and Aurora A kinase in cancer cells.
What is the function of PKD1 and PKD2?
Studies indicate that the loss of protein kinase D PKD1 is thought to promote invasion and metastasis, while PKD2 and upregulated PKD3 to be positive regulators of proliferation. the knockdown of PKD2 reduces cell death and promotes polyploidization induced by PMA.
What is JAK2 protein and why is it important?
The JAK2 protein is especially important for controlling the production of blood cells from hematopoietic stem cells. These stem cells are located within the bone marrow and have the potential to develop into red blood cells, white blood cells, and platelets.
