What is Glycolide used for?
What is Glycolide used for?
Currently polyglycolide and its copolymers (poly(lactic-co-glycolic acid) with lactic acid, poly(glycolide-co-caprolactone) with ε-caprolactone and poly (glycolide-co-trimethylene carbonate) with trimethylene carbonate) are widely used as a material for the synthesis of absorbable sutures and are being evaluated in the …
What is poly DL lactide glycolide?
Poly(D,L-lactide-co-glycolide) is a biodegradable and biocompatible polymer, which is used for drug delivery. It is used to treat rheumatoid arthritis, ulcerative colitis, Crohn′s disease, inflammatory lung diseases and ophthalmic inflammatory disorders.
Is lactic acid or glycolic acid more hydrophobic?
Lactic acid is more hydrophobic than glycolic acid, which makes that lactide-rich PLGA co-polymers are less hydrophilic, absorb less water, and, subsequently, degrade slower. Moreover, stereochemistry plays a major role in PLGA degradation.
What is Glycolide made from?
Poly(lactide-co-glycolide) materials (copolymers of lactic acid and glycolic acid) can be prepared so that their degradation rates range between the poly(lactic acid) and the poly(glycolic acid) extremes.
Is PLGA a natural polymer?
The basic category of biomaterials used in drug delivery can be broadly classified as (1) synthetic biodegradable polymers, which includes relatively hydrophobic materials such as the α-hydroxy acids (a family that includes poly lactic-co-glycolic acid, PLGA), polyanhydrides, and others, and (2) naturally occurring …
Why is PLGA biodegradable?
In water, PLGA biodegrades by hydrolysis of its ester linkages (Figure 2). Presence of methyl side groups in PLA makes it more hydrophobic than PGA and hence lactide rich PLGA copolymers are less hydrophilic, absorb less water and subsequently degrade more slowly.
Where is PLGA used?
PLGA is widely used in bone tissue engineering due to its suitable physico-chemical properties and biodegradability rate; however, compared to natural polymerssuch as collagen and chitosan which have numerous ionic molecular groups, the synthetic polymers have relatively few of these groups, making it very difficult to …
