What is tetrazole used for?

What is tetrazole used for?

Tetrazole, which is usually used as the bioisoster of carboxylic acid, is metabolically stable to many of the biological transformations that the functionality of carboxylic acid is susceptible to in the liver [2].

Are Tetrazoles explosive?

1H-tetrazole is an odorless white to light-yellow crystalline powder. Mp:1 55-157°C. When heated to decomposition it emits toxic oxides of nitrogen fumes. Can explode if exposed to shock or heat from friction or fire.

Are Tetrazoles basic?

The acidic nature of tetrazole is similar to corresponding carboxylic acids, but there is a difference in annular tautomerism of ring tetrazoles to carboxylic acids. The acidic nature of tetrazole is mainly affected by substitution compound nature at C-5 position.

Which among three isomers of tetrazole is Nonaromatic?

In the gas phase, 2H-tetrazole dominates. These isomers can be regarded as aromatic, with 6 π-electrons, while the 5H-isomer is nonaromatic.

Is imidazole a salt?

Salts of imidazole where the imidazole ring is the cation are known as imidazolium salts (for example, imidazolium chloride or nitrate). These salts are formed from the protonation or substitution at nitrogen of imidazole. These salts have been used as ionic liquids and precursors to stable carbenes.

Is Tetrazole soluble in water?

Soluble in water (23 g/100 mL at 20°C) Reacts slowly with water (moisture) with release of corrosive gases (ammonia, nitrogen oxides). Soluble in water.

How do you make Tetrazoles?

An organocatalyst, 5-azido-1-methyl-3,4-dihydro-2H-pyrrolium azide, generated in situ from N-methyl-2-pyrrolidone (NMP), sodium azide, and trimethylsilyl chloride, enables the formation of tetrazoles by cycloaddition of sodium azide with organic nitriles under neutral conditions and microwave heating.

Is pyrazole acidic or basic?

Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C). Pyrazoles are also a class of compounds that have the ring C3N2 with adjacent nitrogen atoms.

How toxic is imidazole?

Imidazole has low acute toxicity as indicated by the LD 50 of 970 mg/kg (Rat, oral).

What are imidazole derivatives?

Many imidazole-based derivatives have been marketed as antifungal drugs such as ketoconazole (1), miconazole (2), clotrimazole (3), tioconazole (4), econazole (5), tinidazole (6), enilconazole/imazalil (7), parconazole (8), eberconazole (9), lanoconazole (10), fenticonazole (11), bifonazole (12), sulconazole (13).

Is triazole basic?

1,2,3-Triazole is one of a pair of isomeric chemical compounds with molecular formula C2H3N3, called triazoles, which have a five-membered ring of two carbon atoms and three nitrogen atoms. 1,2,3-Triazole is a basic aromatic heterocycle.

What is nitroblue tetrazolium salts used for?

The tetrazolium salts have been used extensively for the detection of superoxide in phagocytes. Nitroblue tetrazolium (NBT) is pale yellow in color prior to reduction by superoxide.

What is nitrotetrazolium blue (NTB) exclusion assay?

The nitrotetrazolium blue (NTB) exclusion assay ( Simard, Mourier, Greaves, Taylor, & Stewart, 2018) is a new method used to detect COX deficiency without using DAB.

How do you make tetrazole from nitriles?

Tetrazole was first prepared by the reaction of anhydrous hydrazoic acid and hydrogen cyanide under pressure. Treatment of organic nitriles with sodium azide in the presence of iodine or silica-supported sodium bisulfate as a heterogeneous catalyst enables an advantageous synthesis of 5-substituted 1H-tetrazoles.

What are tetrazole salts used for?

These include the azidotetrazolate salts of nitrogen bases. Other tetrazoles are used for their explosive or combustive properties, such as tetrazole itself and 5-aminotetrazole, which are sometimes used as a component of gas generators in automobile airbags.