What is the difference between simvastatin and ezetimibe?

What is the difference between simvastatin and ezetimibe?

Ezetimibe reduces the amount of cholesterol absorbed by the body. Simvastatin is in a group of drugs called HMG CoA reductase inhibitors, or “statins.”

Is Ezetimibe a cholesterol absorption inhibitor?

Ezetimibe inhibits the absorption of biliary and dietary cholesterol from the small intestine without affecting the absorption of fat-soluble vitamins, triglycerides, or bile acids. Ezetimibe localizes at the brush border of the small intestine and decreases cholesterol uptake into the enterocytes.

Can you take ezetimibe and simvastatin together?

Ezetimibe and simvastatin combination is used together with a proper diet to treat high cholesterol and triglyceride (fats) levels in the blood. This medicine may help prevent medical problems (eg, heart attack, stroke) caused by clogged blood vessels.

What is the most common side effect of statins and ezetimibe?

Common side effects include stomach (abdominal) pain and diarrhoea. Ezetimibe is also known by the brand name Ezetrol. It can also be mixed with simvastatin, a type of statin.

Which is better statins or ezetimibe?

Ezetimibe lowers low-density lipoprotein cholesterol (LDL-C) by 15-20% when used alone2 as compared to 5-10% from doubling the dose of statin.

What are the side effects of cholesterol absorption inhibitors?

Side effects of cholesterol absorption inhibitors are minor and may include stomachaches, diarrhea, fatigue, and headaches. PCSK9 inhibitors may cause side effects including injection-site rash, limb pain, and fatigue.

Can you take a statin and ezetimibe?

The combination therapy is relatively safe. Conclusion: Ezetimibe add-on to statin combination therapy is an effective treatment option that leads to additional LDL-C lowering – recommended in situations where, with a maximal or maximally tolerated statin monotherapy treatment regimen, LDL-C targets cannot be achieved.

Does ezetimibe contain simvastatin?

Vytorin (ezetimibe / simvastatin) is a combination of ezetimibe (Zetia) and simvastatin (Zocor) that is used for treating high levels of cholesterol in the blood. Vytorin (ezetimibe / simvastatin) reduces total cholesterol and “bad” cholesterol (LDL), and it increases “good” cholesterol (HDL).

How long does ezetimibe and simvastatin take to work?

Most people with high cholesterol or triglycerides do not feel sick. It is very important to continue to follow your doctor’s advice about diet and exercise. It may take up to 4 weeks before you get the full benefit of this drug.

How effective is ezetimibe add-on to statin combination therapy?

Ezetimibe add-on to statin combination therapy is an effective treatment option that leads to additional LDL-C lowering – recommended in situations where, with a maximal or maximally tolerated statin monotherapy treatment regimen, LDL-C targets cannot be achieved.

How effective are Statins at reducing risk of Major CV events?

Statins have been proven to be very effective in reducing ASCVD risk, with no apparent threshold at which LDL-C lowering is not associated with reduced risk. Yet, a significant on-treatment residual risk of major cardiovascular (CV) events still exists according to meta-analyses of statin trials.

What are statins used to treat hyperlipidemia?

Statins are the hypolipemic treatment of choice for hyperlipidemia with confirmed atherosclerotic cardiovascular disease (ASCVD) protective effect, proven even in normolipemic patients.