What is the meaning of inbreeding coefficient?
What is the meaning of inbreeding coefficient?
The coefficient of inbreeding (F) is used to define the probability that two alleles will be identical and derived from the same forebear.
How is inbreeding coefficient calculated?
If a child is inbred through more than one line of descent, the total coefficient of inbreeding is the sum of each of the separate coefficients. For example, first cousins are related through two grandparents. Thus, the inbreeding coefficient for the offspring of first cousins is F = (½)5 + (½)5 = (½)4 = 1/16.
What is the range of inbreeding coefficient?
0 to 1
The exponential-p inbreeding coefficient does range from 0 to 1, since it is defined as a probability. The exponential-p inbreeding coefficient requires definition of a threshold, T, which should be the same when comparing inbreeding of different individuals from the same population.
What does it mean when the inbreeding coefficient is negative?
Negative values of Inbreeding Coefficient could mean there are too many heterozygotes and suggest a site with bad mapping.
How does inbreeding affect allele frequencies?
Inbreeding causes a loss of heterozygosity with no expected change in allele frequencies. As alleles are lost, homozygosity necessarily increases. Within any given small population, mean fitness may increase or decrease, depending on whether deleterious or advantageous alleles are lost by drift.
What does COI mean in dog breeding?
Genetic coefficient of inbreeding
Genetic coefficient of inbreeding (COI) is the most accurate method for measuring inbreeding. Unlike pedigree based COI calculations, genetic COI evaluates the actual pieces of DNA in your dog to identify which proportion traces back to inbreeding.
What does an inbreeding coefficient of 0 signify?
Note that two inbred animals that are unrelated themselves will have fully out crossed progeny (inbreeding coefficient of zero). Hence, you can go from inbred to out crossed in one generation.
What is the inbreeding coefficient for self fertilization?
1/2
For example, the inbreeding coefficient of an individual resulting from self-fertilization is 1/2, for an individual resulting from a parent–offspring or brother–sister mating 1/4, for individuals that are half-sibs 1/8, and for cousins 1/16.
