Who anaplastic oligodendroglioma?
Who anaplastic oligodendroglioma?
Anaplastic oligodendroglioma is a neuroepithelial tumor which is believed to originate from oligodendrocytes, a cell type of the glia. In the World Health Organization (WHO) classification of brain tumors, anaplastic oligodendrogliomas are classified as grade III.
What does 1p 19q deletion mean?
Complete deletion of both the short arm of chromosome 1 (1p) and the long arm of chromosome 19 (19q) (1p/19q co-deletion) is the molecular genetic signature of oligodendrogliomas, a subtype of primary brain tumours accounting for approximately ten to fifteen percent of all diffuse gliomas in adults 1,2.
Can oligodendroglioma metastasize?
An oligodendroglioma metastasizes very infrequently. In most cases (96% in one study) (2), extraneural metastasis occurred after surgical excision of the primary tumor. There are several reports of local infiltration of the meninges as well as drop metastases to the spinal cord.
What does IDH mutant mean?
Among numerous genomic alterations, the isocitrate dehydrogenase ( IDH ) mutation is one of the most important genetic alterations found in this kind of tumor. As IDH mutation is a ubiquitous mutation in lower grade gliomas, the development of molecular target therapies against IDH mutations is expected.
Is IDH mutation good?
Prognostically, IDH mutations are one of the strongest prognostic markers in low-grade gliomas, but also high-grade gliomas. In a glioblastoma, for example, if you’re IDH wild-type, which 95% of glioblastomas are, your survivals are in the ballpark of 15 to 18 months.
Can oligodendroglioma spread to spine?
Background: Spinal cord metastasis is an uncommon event in glioblastoma, symptomatic lesions are very rare, and this occurrence in anaplastic oligodendroglioma is exceptional. Only 16 cases of symptomatic spinal cord metastasis from brain oligodendroglioma have been reported in the literature.
